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January 15, 2026The Journal of Organic Chemistry

Sulfur–Sulfur Bond-Driven Synthesis of 3-Thiooxindoles Using Triflic Acid without a Metal or Hydride Source

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Authors

VHVijayakumar HemamaliniMSMarkabandhu ShanthiKPKaruppaiah Perumal

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Overview

This method demonstrates thioether formation from isatin and thiophenol derivatives with moderate yields, indicating synthetic versatility.

Key Points

  • To develop a triflic acid-catalyzed, metal-free protocol for synthesizing 3-thiooxindoles.
  • Utilized isatin and thiophenol derivatives as starting materials.
  • Employed triflic acid as a catalyst under mild conditions.
  • Avoided the use of metal or hydride sources during the synthesis.
  • Achieved moderate to good yields across various substrates.
  • Demonstrated thioether formation from ketones via indolinone.
  • Validated the reaction pathway through mechanistic investigations.

Cite This Study

Hemamalini et al. (2026) studied this question.

synapsesocial.com/papers/69683e135818e7dbd7c63152https://doi.org/10.1021/acs.joc.5c02716
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