Simple and Cost-Effective Chrysin-Theophylline Eutectic: Enhanced Solubility, Dissolution, and Oral Bioavailability with Potential for Respiratory Applications

Key Points

• To evaluate the solubility, dissolution, and oral bioavailability of a chrysin-theophylline eutectic formulation.
• Synthesize chrysin-theophylline eutectic using a simple method.
• Measure solubility and dissolution rates in laboratory conditions.
• Assess oral bioavailability in a relevant model for respiratory applications.
• The eutectic formulation shows significantly improved solubility compared to individual components.
• Dissolution rates indicate faster absorption profiles.
• Oral bioavailability is markedly enhanced, suggesting better therapeutic outcomes for respiratory treatment.