Why the study?
Renal and cardiac dysfunction determine adverse outcomes after TAVR, but the prognostic value of baseline and temporal 48-72 h BUN/EF ratios for predicting mortality had not been evaluated.
Does the baseline and 48-72 h BUN/EF ratio predict mortality in patients undergoing TAVR for severe aortic stenosis?
Population
429 patients who underwent TAVR for severe aortic stenosis
Comparison
Baseline vs temporal (48-72 h) BUN/EF ratios
Design
Retrospective cohort study
Follow-up
Median 733 days
Key result
Baseline and 48-72 h BUN/EF ratios were independently associated with long-term all-cause mortality after TAVR (HR 3.46 and 3.79 per 1 SD increase, respectively; both p<0.001).
Authors
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The 48–72 h BUN/EF ratio was associated with post-TAVR mortality; leaves open whether it improves risk stratification in prospective cohorts.
Cohort (n=429)
Does the baseline and 48-72 h BUN/EF ratio predict mortality in patients undergoing TAVR for severe aortic stenosis?
Hazard Ratio: 3.46
p-value: p=<0.001
The BUN/EF ratio, particularly measured at 48-72 hours post-procedure, is a strong independent predictor of early and long-term mortality after TAVR, improving risk stratification beyond the EuroSCORE II.
Çelik et al. (2026) conducted a cohort in severe aortic stenosis (n=429). BUN/EF ratio (baseline and 48-72 h) was evaluated on long-term all-cause mortality (HR 3.46, p=<0.001). Baseline and 48-72 h BUN/EF ratios were independently associated with long-term all-cause mortality after TAVR (HR 3.46 and 3.79 per 1 SD increase, respectively; both p<0.001).