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January 17, 2026Food Science and Preservation0 citationsOpen Access

Laxative Effects of Prune-Fermented Drink on Constipation in Rats

Laxative effects of prune-fermented drink on loperamide-induced constipation in Sprague-Dawley rats

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Authors

WPWool-Lim ParkHMHye-Ji MinJHJi-An Heo

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Overview

Demonstrates that prune-fermented drink improves intestinal function in rats with induced constipation, suggesting its potential as a functional food.

Key Points

  • The aim is to evaluate the laxative effects of a prune-fermented drink on constipation induced by loperamide in rats.
  • Analysis of fecal and digestive tract parameters in loperamide-treated rats
  • Oral administration of prune-fermented drink to assess its impact on constipation
  • Histological assessment using Alcian blue and PAS staining to evaluate colonic mucosal health
  • Prune-fermented drink significantly increased fecal excretion and fecal weight in loperamide-treated rats
  • Improved fecal water content was observed after PF administration
  • Colonic mucosa showed marked morphological improvement in rats treated with PF compared to loperamide-only group

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/696b25a9d2a12237a934902fhttps://doi.org/10.11002/fsp.2025.32.6.1188
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