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January 17, 2026Pediatric ResearchOpen Access

Putative mechanisms of caffeine as a neuroprotectant in preterm infants

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Authors

MMMadeline A. MacNamaraPCPaul B. ColditzJWJulie A. Wixey

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Overview

This review explores caffeine's neuroprotective effects in preterm infants, highlighting potential mechanisms and implications.

Key Points

  • The aim is to review the mechanisms by which caffeine acts as a neuroprotectant in preterm infants.
  • Literature review of existing studies on caffeine and its effects on preterm infants.
  • Analysis of caffeine's direct and indirect neuroprotective mechanisms.
  • Discussion of potential pathways including inflammation reduction and white matter structure alteration.
  • Caffeine may alter white matter structures in preterm infants.
  • It has potential to reduce inflammation and prevent cell death.
  • Caffeine confers neuromodulatory benefits that may enhance neurodevelopmental outcomes.

Cite This Study

MacNamara et al. (2026) studied this question.

synapsesocial.com/papers/696b25f3d2a12237a9349449https://doi.org/10.1038/s41390-026-04776-0
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