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January 18, 2026Brain and Behavior0 citationsOpen Access

Rehabilitation–Cognition Integrated Care Program for Elderly With Lower Limb Fractures and Cognitive Impairment: Development and Efficacy

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QCQ. ChenXDXiaozhen DingYWYongmin Wei

Key Points

  • The study aims to develop and evaluate an integrated care program addressing rehabilitation and cognition for elderly individuals with lower limb fractures and cognitive impairment.
  • 128 patients were randomly assigned to an integrated care group or a conventional care group.
  • Both groups underwent 12 weeks of intervention.
  • Outcomes were measured using various scales (e.g., FMA, BBS, MoCA, FIM, HADS).
  • Neurotrophic and neuroinflammatory markers were analyzed pre- and post-intervention.
  • Complications, fall recurrence, and nursing satisfaction were documented.
  • Both groups showed improvements in FMA, BBS, and FIM scores, with the integrated group performing significantly better.
  • Anxiety and depression scores decreased more in the integrated group post-intervention.
  • The integrated group had higher MoCA scores compared to its baseline and the conventional group.
  • Levels of BDNF and GDNF increased significantly in the integrated group, while S100-β and IL-6 levels decreased.
  • The integrated group experienced lower complication rates and higher nursing satisfaction.

Abstract

ABSTRACT Objective To develop and assess the efficacy of a rehabilitation–cognition integrated care (RCIC) program for elderly patients with lower limb fractures and mild‐to‐moderate cognitive impairment. Methods A total of 128 eligible patients during January 2023 to December 2024 were randomly allocated to conventional ( n = 64) or integrated care group ( n = 64). Both groups received 12 weeks of intervention. Outcomes, including Fugl‐Meyer Assessment (FMA), Berg Balance Scale (BBS), Montreal Cognitive Assessment (MoCA), Functional Independence Measure (FIM), and Hospital Anxiety and Depression Scale (HADS) scores, were compared. Serum neurotrophic and neuroinflammatory markers were analyzed pre‐ and post‐intervention. Complications, fall recurrence rates, and nursing satisfaction were recorded. Results Post‐intervention, both groups showed improved FMA, BBS, and FIM scores, with significantly greater improvement in the integrated care group ( p 0.05), and higher nursing satisfaction ( p < 0.05). Conclusion The RCIC program significantly enhances motor function, balance, cognition, and psychological status while reducing complications and improving satisfaction in elderly fracture patients with cognitive impairment.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/696c774feb60fb80d1395820https://doi.org/10.1002/brb3.71184
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