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January 18, 20260 citationsOpen Access

Nitazoxanide: A Review of Its Use in the Treatment of Gastrointestinal Infections

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*S*Dr. Shruti Sarwade

Key Points

  • The review aims to evaluate the effectiveness of nitazoxanide in treating gastrointestinal infections caused by protozoa and helminths.
  • Analysis of nitazoxanide's in vitro activity against microorganisms.
  • Review of clinical data on its use for protozoal and helminthic infections.
  • Consideration of its safety and tolerability in different age groups.
  • Nitazoxanide is effective against Cryptosporidium parvum and Giardia lamblia.
  • It is well tolerated in both adults and children.
  • Recommended as a first-line treatment for related gastrointestinal infections.

Abstract

Nitazoxanide is a new thiazolide antiparasitic agent. Nitazoxanide (AliniaR, DaxonR, DexidexR, ParamixR, KidonaxR, ColufaseR, AnnitaR) has in vitro activity against a variety of microorganisms, including a broad range of protozoa and helminths. Nitazoxanide is effective in the treatment of protozoal and helminthic infections, including Cryptosporidium parvum or Giardia lamblia, in immunocompetent adults and children, and is generally well tolerated. Nitazoxanide is a firstline choice for the treatment of illness caused by C. parvum or G. lamblia infection in immunocompetent adults and children, and is an option to be considered in the treatment of illnesses caused by other protozoa and/or helminths. Nitazoxanide has been licensed for the treatment of Giardia intestinalis–induced diarrhea in patients 1 year of age and Cryptosporidum-induced diarrhea in children aged 1–11 years.

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*Dr. Shruti Sarwade (2026) studied this question.

synapsesocial.com/papers/696c7835eb60fb80d139661ehttps://doi.org/10.5281/zenodo.18264849
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