What question did this study set out to answer?

The aim is to develop an efficient one-pot synthesis method for trifluoroethoxy-substituted pyridines.

January 18, 2026

One-pot synthesis of α-(OCH₂CF₃)-substituted pyridines using TFE as a dual solvent–reagent

Key Points

The aim is to develop an efficient one-pot synthesis method for trifluoroethoxy-substituted pyridines.
Utilization of TFE as both solvent and reagent
One-pot reaction approach
Characterization of synthesized pyridines
Evaluation of reaction conditions
Successful synthesis of various α-(OCH₂CF₃)-substituted pyridines
Demonstrated broad applicability in material science
Potential enhancement of pharmaceutical compounds

Abstract

Trifluoroethoxy-substituted pyridines are one of the core components of many biologically active scaffolds, which have a wide range of applications in fields such as materials science, agrochemicals, and pharmaceuticals. The...

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Cite this study

Bhavyesh et al. (Wed,) studied this question.

www.synapsesocial.com/papers/696c789ceb60fb80d1396cd7 — DOI: https://doi.org/10.1039/d5ob01938a

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Authors

Desai Bhavyesh

Arti Ramani

Yash Dhaduk

Journals

Organic & Biomolecular Chemistry

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One-pot synthesis of α-(OCH₂CF₃)-substituted pyridines using TFE as a dual solvent–reagent

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

References and Citations

Citation Network

Connected Papers

Discussion