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January 20, 2026Open Forum Infectious Diseases0 citationsOpen Access

Clinical Characteristics of Patients with Patent Foramen Ovale and Pyogenic Brain Abscess

KAKhalid Abu-ZeinahPDPansachee DamronglerdHTHussam Tabaja

Key Points

  • To explore the association between patent foramen ovale and pyogenic brain abscess characteristics, and to assess mortality rates in these patients.
  • Reviewed medical records of patients with pyogenic brain abscess and known patent foramen ovale status between 2009 and 2021
  • Analyzed prevalence of patent foramen ovale in pyogenic brain abscess patients
  • Assessed clinical characteristics and one-year all-cause mortality rates.
  • Found a high prevalence of patent foramen ovale (40.5%) in pyogenic brain abscess patients
  • Observed distinct abscess characteristics in patients with patent foramen ovale
  • Noted that one-year all-cause mortality remained unchanged despite the presence of patent foramen ovale.

Abstract

Abstract Patent foramen ovale (PFO) has a prevalence of ∼25%. Its association with pyogenic brain abscess (PBA) is unclear. We reviewed adults with PBA and known PFO status from 1/1/2009-12/31/2021 at Mayo Clinic. High PFO prevalence (40.5%) was seen. PBA patients with PFO had distinct abscess characteristics but unchanged one-year, all-cause mortality.

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Cite This Study

Abu-Zeinah et al. (2026) studied this question.

synapsesocial.com/papers/696f1a629e64f732b51eea4fhttps://doi.org/10.1093/ofid/ofag026
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