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January 21, 2026Journal of Asian Natural Products Research0 citations

A new nor-28-oleanane glycoside isolated from Syzygium formosum inhibits nitric oxide production in LPS-stimulated RAW264.7 cells

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PTPham Thi ThamPGPham Thi Thu GiangLHLai Thi Huyen

Key Points

  • The primary aim is to explore the inhibitory effects of a new nor-28-oleanane glycoside on nitric oxide production.
  • Isolated compounds from methanol extract of Syzygium formosum leaves.
  • Utilized HRESIMS and NMR for structural elucidation.
  • Determined absolute configuration using ECD spectra and TD-DFT methods.
  • Assessed nitric oxide production in LPS-stimulated RAW264.7 cells.
  • Syringin demonstrated significant inhibitory activity against NO production with an IC50 of 18.4 μM.
  • Compounds 1-3 showed moderate inhibitory effects with IC50 values ranging from 58.4-79.2 μM.

Abstract

One new nor-28-oleanane glycoside (1) and fifteen known compounds (2 - 16) were separated from a methanol extract of Syzygium formosum leaves. Their structures were elucidated via HRESIMS and NMR spectroscopic analyses. The absolute configuration of 1 was determined based on ECD spectra calculated using TD-DFT methods. Among the isolates, syringin (11) exhibited significant inhibitory activity against NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 18.4 μM. Compounds 1 - 3 displayed moderate inhibitory effects, with IC50 values of 58.4-79.2 μM.

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Cite This Study

Tham et al. (2026) studied this question.

synapsesocial.com/papers/69706c09b6488063ad5c178ahttps://doi.org/10.1080/10286020.2026.2615673
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