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January 21, 2026Acta Oto-Laryngologica1 citationsOpen Access

Oxidative stress and inflammation in age-related hearing loss: temporal dynamics in cochlear degeneration of C57BL/6 mice

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APAnna PisaniBHBrenda HasslerFPFabiola Paciello

Key Points

  • This research aims to explore the connection between oxidative stress and inflammation in age-related hearing loss in mice.
  • Examined the cochlear degeneration in C57BL/6 mice
  • Analyzed the temporal dynamics of oxidative stress and inflammation
  • Identified potential therapeutic targets for preventing presbycusis.
  • Demonstrated a significant correlation between oxidative stress and inflammation in age-related hearing loss
  • Found that the timing of these processes varies, affecting cochlear health
  • Suggested specific targets for therapy to mitigate hearing loss in aging populations.

Abstract

Our findings underscore the role of oxidative stress-inflammation crosstalk in ARHL, suggesting therapeutic targets for preventing presbycusis in aging populations.

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Cite This Study

Pisani et al. (2026) studied this question.

synapsesocial.com/papers/69706c87b6488063ad5c1a8ahttps://doi.org/10.1080/00016489.2025.2598401
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects2023 · 36 citations
  2. 2Noise-Induced Hearing Loss (NIHL) as a Target of Oxidative Stress-Mediated Damage: Cochlear and Cortical Responses after an Increase in Antioxidant Defense2013 · 223 citations
  3. 3Quiet as a mouse: dissecting the molecular and genetic basis of hearing2008 · 142 citations
  4. 4Comments on review of free radicals in biology and medicine, second edition, by Barry Halliwell and John M.C. Gutteridge1992 · 96 citations
  5. 5Decline in Older Persons’ Ability to Recognize Speech in Noise2013 · 60 citations