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January 22, 2026Annals of Medicine4 citationsOpen Access

Choosing real-world data for clinical and epidemiological research: methodological lessons from NHIRD and TriNetX—A narrative review

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TLTeng-Li LinYCYen‐Ju ChenCWChun-Ying Wu

Key Points

  • The aim is to evaluate how to effectively choose and utilize real-world data sources for clinical and epidemiological research.
  • Narrative review of NHIRD and TriNetX databases
  • Comparison of strengths and limitations of each database
  • Discussion of methodological strategies for study design
  • Identified strengths and weaknesses of NHIRD and TriNetX
  • Provided insights into the importance of alignment between research goals and database features
  • Emphasized the role of methodological strategies in supporting valid research findings

Abstract

NHIRD and TriNetX are complementary real-world data sources, each with distinct strengths and limitations. Aligning research objectives with database characteristics is essential for appropriate study design. Recognition of platform-specific trade-offs and application of targeted methodological strategies support the validity and generalizability of real-world evidence.

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Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6971bd90642b1836717e22e3https://doi.org/10.1080/07853890.2026.2616549
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