d -Penicillamine-loaded MIL-100(Fe) for precise targeted copper chelation in Wilson's disease

Key Points

• The aim is to develop a targeted therapy for effective copper chelation in Wilson's disease using a metal-organic framework.
• Utilized MIL-100(Fe) as a delivery system for d-Penicillamine.
• Focused on precise targeting mechanisms for copper chelation.
• Evaluated the effectiveness in Wilson's disease treatment.
• Achieved effective targeting of copper ions.
• Demonstrated improved therapeutic outcomes in Wilson's disease models.
• Showed enhanced stability and release profile of d-Penicillamine.

Abstract