New multitarget antidiabetic potential agents based on sulfaguanidine: design, synthesis, and biological evaluation | Synapse
January 22, 2026Open Access
New multitarget antidiabetic potential agents based on sulfaguanidine: design, synthesis, and biological evaluation
Puntos clave
This research aims to develop new sulfaguanidine-based agents that can effectively manage diabetes by inhibiting key enzymes involved in carbohydrate metabolism.
Designed and synthesized pyrazole/oxazole sulfaguanidine-hydrazone hybrids.
Conducted enzyme inhibition assays for α-glucosidase and α-amylase.
Performed docking studies to analyze interactions between agents and enzymes.
Sulfaguanidine-hydrazone hybrids showed significant dual inhibition of α-glucosidase and α-amylase.
Enhanced glucose uptake was observed in biological evaluation.
Docking studies identified crucial interactions between hybrids and target enzymes.
Resumen
New pyrazole/oxazole sulfaguanidine-hydrazone hybrids demonstrate potent dual α-glucosidase/α-amylase inhibition and enhanced glucose uptake, with docking studies revealing key enzyme interactions.