Factors affecting the likelihood of documented medication concerns in patients with multimorbidity: a cross-sectional study in primary care

Background High-risk patients with chronic conditions in Primary Care often face medication-related problems. A significant but underexplored problem is the patient's medication concern, which may also impact treatment decisions and outcomes. Aim This study aims to describe the characteristics of high-risk patients with chronic conditions in Madrid, Spain, who have documented medications concern and to analyze the associated factors. Design P -value<0.001), polypharmacy OR 3.2 (95%CI:3.1-3.3; P -value<0.001), living alone OR 1.5 (95%CI: 1.4-1.6; P -value<0.001), Parkinson’s OR 1.3 (95%CI: 1.2-1.4; P -value<0.001); chronic pain OR 1.6 (95%CI:1.2-2.1; P -value=0.001), and cardiovascular risk factors OR 1.2 (95%CI: 1.1-1.3; P -value=0.001) were associated with medication concern. Conclusion Age, polypharmacy, multimorbidity, and social isolation are predictors of medication concern in high-risk chronic patients in Primary Care. Addressing psychological barriers, simplifying treatment, and strengthening social support through tailored interventions could decrease medication concerns.