Demonstrates enhanced bioavailability of curcumin and controlled release of fucoxanthin using multilayer emulsions, implying improved delivery in the gastrointestinal tract.
Key Points
The research aims to evaluate the programmed release and bioavailability of curcumin and fucoxanthin using solid-in-oil-in-water multilayer emulsions.
Constructed solid-in-oil-in-water multilayer emulsions for co-encapsulation of curcumin and fucoxanthin.
Evaluated release behavior through in vitro digestion models.
Assessed in vivo bioavailability using fluorescence imaging.
Less than 16.5% of curcumin and fucoxanthin were released in simulated gastric fluid.
Curcumin was released in 67.3% during simulation of intestinal fluid due to erosion.
60.3% of fucoxanthin was released into simulated colonic fluid, primarily through erosive mechanisms.
Curcumin bioavailability was enhanced by 6.4-fold in the small intestine.