What question did this study set out to answer?

To investigate the neuroprotective effects of Naoluotong granules by inhibiting necroptosis via specific signaling pathways.

January 22, 2026

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Naoluotong granules inhibit necroptosis of neural cells and improve cerebral ischemia-reperfusion injury by regulating the RIP1/NIK/IKKα/NF-κB pathway.

YLYajun LiJilin University WDWei DongAnhui University of Traditional Chinese Medicine LLLiangyong LiAnhui University of Traditional Chinese Medicine

Key Points

To investigate the neuroprotective effects of Naoluotong granules by inhibiting necroptosis via specific signaling pathways.
Analyzed the effects of Naoluotong granules and AST-IV on cell necrosis.
Investigated the RIP1/NIK/IKKα/NF-κB signaling pathway in neural cells.
Assessed outcomes related to cerebral ischemia-reperfusion injury.
Naoluotong granules significantly inhibited necroptosis in neural cells.
The intervention improved outcomes related to cerebral ischemia-reperfusion injury.
Regulation of the RIP1/NIK/IKKα/NF-κB pathway was confirmed.

Abstract

This study confirms that the significant neuroprotective effects of NLT and AST-IV in alleviating CIRI are related to inhibiting necrosis by suppressing the RIP1/NIK/IKKα/NF-κB pathway.

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Naoluotong granules inhibit necroptosis of neural cells and improve cerebral ischemia-reperfusion injury by regulating the RIP1/NIK/IKKα/NF-κB pathway.

Key Points

Abstract

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