Naoluotong granules inhibit necroptosis of neural cells and improve cerebral ischemia-reperfusion injury by regulating the RIP1/NIK/IKKα/NF-κB pathway.
To investigate the neuroprotective effects of Naoluotong granules by inhibiting necroptosis via specific signaling pathways.
Analyzed the effects of Naoluotong granules and AST-IV on cell necrosis.
Investigated the RIP1/NIK/IKKα/NF-κB signaling pathway in neural cells.
Assessed outcomes related to cerebral ischemia-reperfusion injury.
Naoluotong granules significantly inhibited necroptosis in neural cells.
The intervention improved outcomes related to cerebral ischemia-reperfusion injury.
Regulation of the RIP1/NIK/IKKα/NF-κB pathway was confirmed.
Resumen
This study confirms that the significant neuroprotective effects of NLT and AST-IV in alleviating CIRI are related to inhibiting necrosis by suppressing the RIP1/NIK/IKKα/NF-κB pathway.
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Naoluotong granules inhibit necroptosis of neural cells and improve cerebral ischemia-reperfusion injury by regulating the RIP1/NIK/IKKα/NF-κB pathway. | Synapse