Abstract Background Crohn’s disease (CD) commonly affects women of childbearing age. Knowledge about the impact of the disease and its treatments on pregnancy influences reproductive decisions and treatment adherence. Data on this topic remain scarce in middle-income countries. The aims of our study were to assess the knowledge of female patients with CD regarding pregnancy and to analyze the factors associated with a low level of knowledge. Methods A cross-sectional study was conducted between January and July 2025, including 30 women with CD. Participants completed the validated CC-Know questionnaire, which assesses pregnancy-related knowledge among women with inflammatory bowel disease. It comprises 17 multiple-choice questions with one correct answer each. One point is awarded per correct response, yielding a total score between 0 and 17. Knowledge levels were classified as poor (0–7), adequate (8–10), good (11–13), or very good (14–17). Sociodemographic characteristics, socioeconomic level, disease phenotype, and ongoing treatments were also collected. Results The mean age of participants was 29 ± 6 years, and 22 women (73%) had a low socioeconomic status. Ileocolonic disease was predominant (15 patients, 50%), followed by isolated ileal (9, 30%) and colonic disease (6, 20%). Perianal involvement was present in 18 women (60%). Regarding treatment, 12 patients (40%) received azathioprine, 7 (23%) were on anti-TNFα monotherapy, and 11 (37%) received combination therapy (azathioprine plus anti-TNFα). The mean CC-Know score was 7.8 ± 2.5/17, with 18 women (60%) showing a poor level of knowledge. Knowledge gaps mainly concerned drug safety during pregnancy, relapse risk, and delivery mode. Age did not significantly influence knowledge scores. Most women did not discuss family planning with their gynaecologist; these topics were mainly addressed during gastroenterology follow-up. Low socioeconomic status and low educational level were significantly associated with poorer knowledge scores (p = 0.02; p = 0.01). Conclusion A substantial knowledge deficit regarding pregnancy exists among women of childbearing age with CD, particularly among those with low educational and socioeconomic levels. These findings highlight the need for a multidisciplinary educational approach to optimise reproductive planning and treatment adherence. Conflict of interest: Dr. Sahbani, Feriel: No conflict of interest Hassine, Hajer: No conflict of interest dabbebi, habiba: No conflict of interest yacoub, haythem: No conflict of interest cherif, dhouha: No conflict of interest kchir, hela: No conflict of interest Maamouri, Nadia: No conflict of interest
Sahbani et al. (2026) studied this question.