Objective: The objective of this systematic review is to analyze the incidence and prevalence of atopic disease in second- and subsequent-generation immigrants from Asia in Australia. Introduction: Atopic diseases are IgE-mediated hypersensitivity diseases that have increased significantly globally. Western countries have conspicuously more incidences of atopic disease than Eastern countries. An increase in second-generation immigrants in Australia has revealed an emerging disparity between the atopic profile of first-generation immigrants, second-generation immigrants, and non-immigrants. Second-generation immigrants from Asia seem to be markedly more susceptible to atopic disease than non-immigrants and their first-generation parents. Eligibility criteria: Studies including atopic disease, specifically food allergies, asthma, atopic dermatitis (eczema), and allergic rhinitis (hay fever), will be included; other presentations of atopic disease will be excluded. The population of interest will be second-generation Asian immigrants and any subsequent generations. Each paper’s definition of Asian will be accepted as presented. The context of interest is Australia. Methods: This systematic review will follow JBI methodology and the PERSyst manual for systematic reviews of prevalence and incidence. PubMed, Scopus, CINAHL, and Embase will be searched for English-language studies from 1990 to the present. Gray literature and trial registries will also be searched. Prevalence and incidence data will be screened against the eligibility criteria and critically appraised by 2 independent reviewers. Data such as age, gender, and country of origin will be extracted via a customized tool. The data will undergo meta-analysis and be presented in narrative format with figures and tables where statistical pooling is not possible. Review registration: PROSPERO CRD42024612805
Lee et al. (2026) studied this question.