Mzb1 Promotes Progression of Schistosomiasis by Inducing Endoplasmic Reticulum Stress.

Key Points

• To explore the role of Mzb1 in promoting liver fibrosis and splenomegaly in schistosomiasis through ER stress activation.
• Identified Mzb1 as a key factor in schistosomiasis pathology.
• Analyzed liver fibrosis and splenomegaly in affected models.
• Assessed the role of ER stress in liver damage.
• Mzb1 activation leads to increased liver fibrosis.
• Mzb1 promotes splenomegaly in schistosomiasis.
• Targeting Mzb1 may have therapeutic potential for treating liver fibrosis.