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January 23, 2026

Direct Difunctionalization of Unsaturated Peptides: A Strategy for Concurrent Incorporation of Trifluoromethyl and Alkynyl Groups.

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Authors

XDXing-Xing DingXPXiang PuLDLin Dong

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Overview

Demonstrates a new method to incorporate alkyne and trifluoromethyl groups into peptides, suggesting a practical approach for creating multifunctional structures.

Key Points

  • The aim is to achieve simultaneous incorporation of alkyne and trifluoromethyl groups into unsaturated peptides.
  • Developed a metal-free trifluoromethylalkynylation process
  • Utilized a low-cost trifluoromethylation reagent
  • Applied mild reaction conditions
  • Focused on unsaturated amino acids and peptides
  • Successfully incorporated both alkyne and trifluoromethyl groups into peptides
  • Demonstrated the method's practicality and versatility
  • Provided access to valuable multifunctional peptide scaffolds

Cite This Study

Ding et al. (2026) studied this question.

synapsesocial.com/papers/69730f34c8125b09b0d1f041https://doi.org/10.1021/acs.orglett.5c05109
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metal‐Free Multifunctionalization of Alkynes Promoted by Acid and Selectfluor2026
  2. 2Catalytic C(<i>sp</i><sup>3</sup>)–H Trifluoroethylation of Amino Acids and Carboxylic Acids2024 · 4 citations
  3. 3Controllable Phosphorothiotrifluoromethylation and Hydrotrifluoromethylation of Unactivated Alkenes in Water2025
  4. 4A C <sub>1</sub> -Homologative Trifluoromethylation: Light-Driven Decarboxylative Trifluoroethylation of Carboxylic Acids2026 · 2 citations
  5. 5Nickel‐Catalyzed Reductive Cross‐Coupling of α‐Trifluoromethylated Alkyl Electrophiles and Allylic Sulfones2024 · 2 citations