What question did this study set out to answer?

To assess the efficacy, tolerability, and safety of ultra-low dosage polyethylene glycol bowel preparation in patients with ulcerative colitis.

January 23, 2026Journal of Crohn s and Colitis0 citations

P0274The efficacy and tolerability of ultra-low dosage polyethylene glycol based modified bowel preparation in patients with Uulcerative Colitis: A multicenter randomized controlled trial

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HXH Xu HYH Yang HXHui Xu

Key Points

To assess the efficacy, tolerability, and safety of ultra-low dosage polyethylene glycol bowel preparation in patients with ulcerative colitis.
Prospective multicenter randomized controlled trial
Patients aged 18-70 with a diagnosis of ulcerative colitis
Random assignment to 1L or 3L polyethylene glycol and enteral nutrition diet
Assessments using Boston Bowel Preparation Score and questionnaires
Mean BBPS scores were non-inferior: 6.80 for 1L vs 7.24 for 3L PEG (p=0.0007)
Higher tolerability score in 1L group: 8.28 vs 7.63 (p=0.001)
1L PEG group showed greater willingness to repeat preparation (p=0.014)
Adverse reactions were more common in the 3L group, particularly nausea (28% vs 14.5%, p=0.007)

Abstract

Abstract Hui Xu1 Junmei Zhang2 Lin Liu3 Li Wang6 Wei Han6 Xinjuan Liu7 Yanjun Chen8 Yue Yang9 Zuoyan Wu10 Xuren Sun4* Linting Xun5* Hong Yang1* 1. Peking Union Medical College Hospital Chinese Academy of Medical Sciences 9. 2. Murthy SK, Feuerstein JD, Nguyen GC, et al. AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review. Gastroenterology 2021;161:1043–1051.e4. 3. Chatterjee A, Kaur S, Jena A, et al. Strategies to Improve Colonoscopy Preparation in Inflammatory Bowel Disease. A Systematic Review and Network Meta-analysis of Randomized Trials. J Of Gastrointest And Liver Diseases 2024;33:245–253. 4. Megna B, Weiss J, Ley D, et al. Clear liquid diet before bowel preparation predicts successful chromoendoscopy in patients with inflammatory bowel disease. Gastrointest Endoscopy 2019;89:373–379.e2. Conflict of interest: Dr. Xu, Hui: No conflict of interest Yang, Hong: No conflict of interest

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69730f59c8125b09b0d1f266 https://doi.org/10.1093/ecco-jcc/jjaf231.455

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January 23, 2026Journal of Crohn s and Colitis0 citations

P0274The efficacy and tolerability of ultra-low dosage polyethylene glycol based modified bowel preparation in patients with Uulcerative Colitis: A multicenter randomized controlled trial

View Full Paper

HXH Xu HYH Yang HXHui Xu

Key Points

To assess the efficacy, tolerability, and safety of ultra-low dosage polyethylene glycol bowel preparation in patients with ulcerative colitis.
Prospective multicenter randomized controlled trial
Patients aged 18-70 with a diagnosis of ulcerative colitis
Random assignment to 1L or 3L polyethylene glycol and enteral nutrition diet
Assessments using Boston Bowel Preparation Score and questionnaires
Mean BBPS scores were non-inferior: 6.80 for 1L vs 7.24 for 3L PEG (p=0.0007)
Higher tolerability score in 1L group: 8.28 vs 7.63 (p=0.001)
1L PEG group showed greater willingness to repeat preparation (p=0.014)
Adverse reactions were more common in the 3L group, particularly nausea (28% vs 14.5%, p=0.007)

Abstract

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69730f59c8125b09b0d1f266 https://doi.org/10.1093/ecco-jcc/jjaf231.455

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