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January 23, 2026PathogensOpen Access

Anthelmintic Activity of Protocatechuic Acid Against Ivermectin-Susceptible and Resistant Haemonchus contortus Strains

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Authors

JCJorge Alberto Cortes-MoralesAOAgustín Olmedo‐JuárezMGManasés González-Cortazar

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Overview

Experiment investigates protocatechuic acid's effect on helminth eggs and larvae, suggesting alternative treatment for resistant strains.

Key Points

  • Investigate the anthelmintic activity of protocatechuic acid against ivermectin-susceptible and resistant strains of Haemonchus contortus.
  • Conducted egg hatch inhibition assays on HcIVM-S and HcIVM-R strains
  • Performed larval mortality assays at various concentrations
  • Used protocatechuic acid from Chamaecrista nictitans for testing
  • CnF4 fraction showed over 90% egg hatch inhibition at 0.8 mg/mL against HcIVM-S
  • Commercial protocatechuic acid achieved 97.49% egg hatch inhibition at 0.25 mg/mL against HcIVM-S
  • Larval mortality was 72.4% for HcIVM-S at 8 mg/mL and 53.2% for HcIVM-R at 16 mg/mL

Cite This Study

Cortes-Morales et al. (2026) studied this question.

synapsesocial.com/papers/69730f9fc8125b09b0d1f5d8https://doi.org/10.3390/pathogens15010117
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