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January 23, 20260 citations

Cardiac Troponin Thresholds in Children and Young Adults: A Multi-Center Cohort Study.

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ATAlexander J F ThurstonEREirik Åsen RøysRRRagnhild Røysland

Key Result

Pediatric-specific 97.5th percentile URLs for cardiac troponin would enhance myocardial injury classification in children and young adults.

Key Points

  • To evaluate the impact of pediatric-specific cardiac troponin thresholds on identifying myocardial injury in children and young adults.
  • Conducted a multi-center cohort study
  • Analyzed cardiac troponin levels in youth
  • Compared results against established thresholds
  • Elevating cTn thresholds increased myocardial injury classification
  • Clinical implications remain unclear
  • Need for further research on cTn testing trends

Structured PICO

Does the use of pediatric-specific 97.5th percentile URLs for cTn increase the classification of myocardial injury in children and young adults?

P
Population
Children and young adults
I
Intervention
Pediatric-specific 97.5th percentile upper reference limits (URLs) for cardiac troponin (cTn)
O
Outcome
Classification of myocardial injurysurrogate

Applying pediatric-specific 97.5th percentile URLs for cardiac troponin increases the classification of myocardial injury in children and young adults, though the clinical implications remain uncertain.

Limitations

  • Clinical implications of the increased classification are uncertain and require further study

Abstract

The use of pediatric-specific 97.5th percentile URLs for cTn would increase classification of myocardial injury in children and young adults. The clinical implications of this are uncertain and require further study given cTn testing has increased over the last decade.

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Cite This Study

Thurston et al. (2026) studied this question. Pediatric-specific 97.5th percentile URLs for cardiac troponin would enhance myocardial injury classification in children and young adults.

synapsesocial.com/papers/69730f9fc8125b09b0d1f67ahttps://doi.org/10.1093/jalm/jfaf205
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