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January 23, 20260 citations

Long-acting HIV pre-exposure prophylaxis integrated with community-based sexual and reproductive health services in South Africa (LAPIS): study protocol for a hybrid (1a) cluster randomised controlled phase 3B trial of effectiveness and implementation.

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JBJacob BusangTZThembelihle ZumaNCNatsayi Chimbindi

Key Points

  • The study aims to evaluate the effectiveness and implementation of long-acting HIV pre-exposure prophylaxis integrated with community-based sexual and reproductive health services.
  • Conducting a hybrid (1a) cluster randomized controlled trial
  • Involving community-based sexual and reproductive health services
  • Focusing on effectiveness and implementation in South Africa
  • Expected to provide insights on the combined approach to HIV prevention
  • Aims to demonstrate improved access to reproductive health services
  • May reveal effectiveness in reducing HIV transmission rates

Abstract

ClinicalTrials.gov Identifier-NCT06250504. Registered: 01 February 2024.

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Cite This Study

Busang et al. (2026) studied this question.

synapsesocial.com/papers/69730f9fc8125b09b0d1f68chttps://doi.org/10.1186/s12889-025-24889-1
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