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January 23, 2026Health Science Reports0 citationsOpen Access

Adoption of a Drug Adherence App to Improve Medication Adherence: A Randomized Controlled Trial

MWMek WongCZClaire Chenwen ZhongSWS N Wong

Key Result

The "My eDrug Manager" app improved medication adherence in seniors, with the intervention group achieving a mean MMAS-8 score of 7.06 compared to 6.56 in the control group (p < 0.001).

Key Points

  • The study aims to evaluate the effect of the 'My eDrug Manager' app on medication adherence and blood pressure management in older adults with hypertension.
  • Randomized controlled trial design
  • 569 older adults with hypertension were included
  • Intervention group used the 'My eDrug Manager' app
  • Control group received standard care instructions
  • Adherence measured with Morisky Medication Adherence Scale at 3, 6, and 12 months
  • Intervention group showed significantly higher mean MMAS-8 score at 12 months (7.06) compared to control group (6.56, p < 0.001)
  • 68.6% of intervention group reached optimal adherence compared to 57.6% in control group (p = 0.007)
  • No significant differences in blood pressure control between groups

Structured PICO

Does the 'My eDrug Manager' mobile app improve medication adherence and blood pressure control in older adults with hypertension and poor baseline adherence?

P
Population
569 community-dwelling older adults aged ≥40 years with hypertension, taking at least one antihypertensive medication, possessing a mobile phone, and demonstrating poor medication adherence (MMAS-8 ≤6). Mean age 62.48 years.
I
Intervention
"My eDrug Manager" mobile app installed on smartphones, with 45-60 minutes of baseline training (one-on-one coaching) and adherence pamphlets.
C
Comparator
Usual care based on patient care guidelines, along with the same adherence pamphlet provided at baseline.
O
Outcome
Blood pressure and medication adherence (measured by the Morisky Medication Adherence Scale, MMAS-8) at baseline, 3, 6, and 12 months.patient reported

The implementation of a medication management mobile app significantly improved self-reported medication adherence at 12 months among older adults with hypertension, though it did not translate to significant improvements in blood pressure control.

Limitations

  • Medication adherence was measured by self-administered MMAS-8 score, which is based on patients' self-perception and prone to bias
  • Baseline imbalance in daily sitting time between control and intervention groups
  • Longer follow-up periods (e.g., 3, 5, and 10 years) are needed to provide more comprehensive results
  • The observed difference in adherence may not represent a meaningful clinical improvement

Abstract

ABSTRACT Background and Aims The “My eDrug Manager” app provides Hong Kong patients with detailed medication guidance and reminders, but its impact on medication adherence and blood pressure control among older adults with hypertension is not well‐studied. This study aims to assess the impact of the “My eDrug Manager” mobile app on medication adherence and blood pressure control in hypertensive older adults in Hong Kong. Methods This randomized controlled trial included 569 older adults who were on antihypertensive medication, possessed a smartphone, but demonstrated poor medication adherence. Participants were randomly assigned to either the intervention group, which used the “My eDrug Manager” app and received baseline instructions and adherence pamphlets, or the control group, which received standard care instructions and the same pamphlet. Adherence was measured using the Morisky Medication Adherence Scale (MMAS‐8), with data collected at 3, 6, and 12 months. Statistical comparisons between groups were conducted using t‐tests and chi‐square tests. Results At 12 months, the intervention group had a significantly higher mean MMAS‐8 score (7.06 ± 1.40) compared to the control group (6.56 ± 1.44, p < 0.001). The proportion of participants with optimal adherence was also higher in the intervention group (68.6% vs. 57.6%, p =0.007). However, no significant differences in blood pressure control were observed between the groups. Conclusion The application demonstrates the potential to improve medication adherence among older adults with hypertension, highlighting the need for integrating digital tools into care programs while also pursuing additional strategies for better blood pressure control.

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Cite This Study

Wong et al. (2026) studied this question. The "My eDrug Manager" app improved medication adherence in seniors, with the intervention group achieving a mean MMAS-8 score of 7.06 compared to 6.56 in the control group (p < 0.001).

synapsesocial.com/papers/69731005c8125b09b0d1fc83https://doi.org/10.1002/hsr2.71729
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