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January 23, 2026Journal of Crohn s and Colitis0 citations

Optimizing Biologic Therapy Improves Outcomes in Ulcerative Colitis

DOP028Treat-to-target optimization is effective on endoscopic and histologic outcomes in a real-life cohort of ulcerative colitis – the TACTIC-UC Study

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Authors

GPG PriviteraCBC BezzioABArianna Dal Buono

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Overview

Retrospective study shows treat-to-target strategies improve endoscopic and histologic outcomes in UC patients, indicating effective management pathways.

Key Points

  • The study aims to evaluate the effectiveness of endoscopy-guided optimization of biologic therapy in achieving deeper healing in ulcerative colitis patients with minimal symptoms.
  • Conducted a single-center, retrospective evaluation of ulcerative colitis patients.
  • Included patients with mild symptoms but severe endoscopic activity.
  • Assessed mucosal healing and remission rates within one year post-optimization.
  • 54.2% achieved mucosal healing within one year.
  • 28.8% reached endoscopic remission, while 20.9% achieved histo-endoscopic mucosal remission.
  • Anti-TNF therapies showed significantly better outcomes compared to other biologics.
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Cite This Study

Privitera et al. (2026) studied this question.

synapsesocial.com/papers/69731022c8125b09b0d1fd02https://doi.org/10.1093/ecco-jcc/jjaf231.065
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