What question did this study set out to answer?

This research investigates how hepcidin, an iron-regulating hormone, is influenced by iron status and inflammation in Crohn’s disease and ulcerative colitis.

January 23, 2026Journal of Crohn s and Colitis0 citations

Distinct Hepcidin Dynamics in Crohn’s Disease and Ulcerative Colitis

P0463Distinct Hepcidin Dynamics in Crohn’s Disease and Ulcerative Colitis: Links to Iron Homeostasis and Inflammatory Activity

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Authors

FMFrancisco A. Costa Magro MSM P Ministro dos Santos HSH Tavares de Sousa

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Overview

Cross-sectional study characterizes hepcidin regulation in IBD, revealing links to iron status and inflammation.

Key Points

This research investigates how hepcidin, an iron-regulating hormone, is influenced by iron status and inflammation in Crohn’s disease and ulcerative colitis.
Cross-sectional multicenter study involving 589 individuals with stratification by disease status and iron levels.
Measurement of serum hepcidin, iron parameters, and inflammatory markers such as C-reactive protein and faecal calprotectin.
Analysis using multivariable linear regression to identify predictors of hepcidin levels.
In Crohn's disease, hepcidin levels were higher than controls in certain iron status categories, with a positive correlation to C-reactive protein.
In ulcerative colitis, hepcidin showed no significant difference from controls and correlated negatively with faecal calprotectin.
Ferritin emerged as the strongest independent predictor of hepcidin levels across all groups.

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Magro et al. (2026) studied this question.

synapsesocial.com/papers/69731022c8125b09b0d1fe79 https://doi.org/10.1093/ecco-jcc/jjaf231.644

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January 23, 2026Journal of Crohn s and Colitis0 citations

Distinct Hepcidin Dynamics in Crohn’s Disease and Ulcerative Colitis

P0463Distinct Hepcidin Dynamics in Crohn’s Disease and Ulcerative Colitis: Links to Iron Homeostasis and Inflammatory Activity

View Full Paper

Authors

FMFrancisco A. Costa Magro MSM P Ministro dos Santos HSH Tavares de Sousa

Discussion

Member takes

Overview

Cross-sectional study characterizes hepcidin regulation in IBD, revealing links to iron status and inflammation.

Key Points

This research investigates how hepcidin, an iron-regulating hormone, is influenced by iron status and inflammation in Crohn’s disease and ulcerative colitis.
Cross-sectional multicenter study involving 589 individuals with stratification by disease status and iron levels.
Measurement of serum hepcidin, iron parameters, and inflammatory markers such as C-reactive protein and faecal calprotectin.
Analysis using multivariable linear regression to identify predictors of hepcidin levels.
In Crohn's disease, hepcidin levels were higher than controls in certain iron status categories, with a positive correlation to C-reactive protein.
In ulcerative colitis, hepcidin showed no significant difference from controls and correlated negatively with faecal calprotectin.
Ferritin emerged as the strongest independent predictor of hepcidin levels across all groups.

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View Full Paper

Cite This Study

Magro et al. (2026) studied this question.

synapsesocial.com/papers/69731022c8125b09b0d1fe79 https://doi.org/10.1093/ecco-jcc/jjaf231.644

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