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The aim is to explore advancements in single-atom skeletal editing of aromatic compounds, focusing on carbon-to-nitrogen and nitrogen-to-carbon transformations.

January 23, 2026European Journal of Organic Chemistry7 citations

Advances in Single-Atom Skeletal Editing of Aromatic Compounds

Single‐Atom Skeletal Editing of Aromatics: Advances in Carbon‐to‐Nitrogen and Nitrogen‐to‐Carbon Transmutation

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Authors

AKAnkit Kachore VAVarun Aggarwal EBEkta Bala

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Overview

This review summarizes recent developments in carbon-to-nitrogen and nitrogen-to-carbon transmutations in aromatic systems, indicating promising advances in organic synthesis.

Key Points

The aim is to explore advancements in single-atom skeletal editing of aromatic compounds, focusing on carbon-to-nitrogen and nitrogen-to-carbon transformations.
Overview of recent innovations in C-to-N and N-to-C transmutation techniques.
Discussion of oxidative ring expansion, electrophilic rearrangement, and ring-opening strategies.
Review of synthetic applications in medicinal chemistry, particularly for drug design.
C-to-N transformations successfully convert quinolines into quinazolines, which are important for pharmaceuticals.
N-to-C editing techniques allow the transformation of nitrogen-containing heterocycles into substituted benzenes.
These methodologies enhance drug design, late-stage functionalization, and diversification of heterocycles.

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Kachore et al. (2026) studied this question.

synapsesocial.com/papers/69731089c8125b09b0d203b2 https://doi.org/10.1002/ejoc.202501188

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January 23, 2026European Journal of Organic Chemistry7 citations

Advances in Single-Atom Skeletal Editing of Aromatic Compounds

Single‐Atom Skeletal Editing of Aromatics: Advances in Carbon‐to‐Nitrogen and Nitrogen‐to‐Carbon Transmutation

View Full Paper

Authors

AKAnkit Kachore VAVarun Aggarwal EBEkta Bala

Discussion

Member takes

Overview

This review summarizes recent developments in carbon-to-nitrogen and nitrogen-to-carbon transmutations in aromatic systems, indicating promising advances in organic synthesis.

Key Points

The aim is to explore advancements in single-atom skeletal editing of aromatic compounds, focusing on carbon-to-nitrogen and nitrogen-to-carbon transformations.
Overview of recent innovations in C-to-N and N-to-C transmutation techniques.
Discussion of oxidative ring expansion, electrophilic rearrangement, and ring-opening strategies.
Review of synthetic applications in medicinal chemistry, particularly for drug design.
C-to-N transformations successfully convert quinolines into quinazolines, which are important for pharmaceuticals.
N-to-C editing techniques allow the transformation of nitrogen-containing heterocycles into substituted benzenes.
These methodologies enhance drug design, late-stage functionalization, and diversification of heterocycles.

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Helpful

Bookmark

View Full Paper

Cite This Study

Kachore et al. (2026) studied this question.

synapsesocial.com/papers/69731089c8125b09b0d203b2 https://doi.org/10.1002/ejoc.202501188

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View Full Paper