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January 24, 2026Biophysics Reviews0 citationsOpen Access

Seeing into Hi-C: How our scientific connectivity revealed the close connections in our DNA to be a work of art

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MGMary GriffithsCACaroline A. AustinJDJob Dekker

Key Points

  • The research aims to explore the aesthetic aspects of Hi-C chromatin interaction maps and their significance in understanding DNA structure.
  • Combined artistic representations with scientific data analysis
  • Utilized Hi-C chromatin interaction maps to illustrate structural features
  • Engaged in local and global collaborations for data interpretation
  • Hi-C maps displayed striking checker-board patterns, indicating intricate chromatin organization
  • Artistic interpretations highlighted both short-range and long-range genomic contacts
  • The collaboration illustrated the compelling relationship between data aesthetics and scientific insights

Abstract

Scientific data can be beautiful. An example where the data itself have a particularly striking appearance even before any scientific meaning has been ascribed is the so-called “Hi-C” chromatin interaction map with its distinct checker-board patterns which when combined with simulations have revealed the complex structure of the folded genome. Here, we describe an art-science collaboration which arose through combining local and global inter-personal connections, and which illustrates the equivalent short- and long-range contacts within folded genomes.

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Cite This Study

Griffiths et al. (2026) studied this question.

synapsesocial.com/papers/6974602bbb9d90c67120a07fhttps://doi.org/10.1063/5.0283280
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