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January 24, 20260 citations

Genome-wide CRISPR screen identifies ACSL3 as a regulator of lipotoxicity and progression of MASLD.

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YMYuta MyojinTKTakahiro KodamaRTRyo Takahashi

Key Points

  • This research aims to explore the role of ACSL3 in lipotoxicity and the progression of MASLD.
  • Conducted a genome-wide CRISPR screen
  • Focused on identifying genes regulating lipotoxicity
  • Analyzed the role of ACSL3 in hepatocytes
  • Investigated mechanisms linking lipid droplets to cell injury
  • ACSL3 was identified as a central regulator of lipotoxicity
  • Link between ACSL3 and the formation of inflammatory niches was established
  • Findings support ACSL3 as a potential therapeutic target in steatotic liver disease

Abstract

ACSL3 is a central regulator of lipotoxic hepatocyte injury and MASLD progression, mechanistically linking lipid-droplet biogenesis to apoptosis and inflammatory niche formation. These data suggest that ACSL3 is a promising therapeutic target and support further translational studies to evaluate ACSL3 modulation in steatotic liver disease.

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Cite This Study

Myojin et al. (2026) studied this question.

synapsesocial.com/papers/6974602bbb9d90c67120a17chttps://doi.org/10.1097/hc9.0000000000000884
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