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January 24, 20260 citations

Study of the Mechanism of Mahuang Lianqiao Chixiaodou Decoction against IgA Nephropathy Based on a Combined Strategy of Transcriptomics and Network Pharmacology Analysis.

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YLYajing LiYXYali XiLYLulu Yue

Key Points

  • This research aims to explore how Mahuang Lianqiao Chixiaodou Decoction (MLCD) affects IgA nephropathy through specific signaling pathways.
  • Utilized transcriptomics to identify gene expressions associated with IgA nephropathy
  • Applied network pharmacology to analyze the interactions of MLCD components
  • Examined effects on the TLR9/MAPK/NF-κB signaling pathway in IgAN models
  • MLCD effectively reduces the inflammatory response in IgA nephropathy models
  • Significant improvement in kidney function observed
  • Regulation of the TLR9/MAPK/NF-κB signaling pathway confirmed as a key mechanism

Abstract

MLCD can reduce the inflammatory response and improve kidney function in IgAN models by regulating the TLR9/MAPK/NF-κB signaling pathway.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6974606dbb9d90c67120a4cdhttps://doi.org/10.2174/0113862073396675251027052050
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms of Liancao Xueniao Capsules in Treating Hematuria Associated with IgA Nephropathy: Network Pharmacology and Experimental Validation2026
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  3. 3Discussion on the Potential Mechanism of Wuling Decoction in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology2026
  4. 4Therapeutic Mechanisms of Jinshuiqing in IgA Nephropathy: A Transcriptomic Analysis2025 · 1 citations
  5. 5Integrated network pharmacology, molecular docking, and lipidomics to reveal the regulatory effect of Qingxuan Zhike granules on lipid metabolism in lipopolysaccharide‐induced acute lung injury2024 · 4 citations