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January 24, 2026Asian Pacific Journal of Cancer Prevention0 citationsOpen Access

NF-κB (p65, p50), IL-18, and IL-10 as Therapeutic Targets in Prostate Cancer and BPH: Molecular Insights into Inflammation-Driven Pathogenesis

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SDShailendra DwivediSSSapna SainiAPAjay Panwar

Key Points

  • The aim is to explore the roles of NF-κB, IL-18, and IL-10 as therapeutic targets in prostate cancer and benign prostatic hyperplasia (BPH).
  • Analysis of NF-κB and its associated cytokines in prostate cancer and BPH samples.
  • Evaluation of cytokine levels as noninvasive biomarkers for diagnosis and staging.
  • Investigation of the relationship between environmental factors and biomarker expression.
  • NF-κB activity correlates with IL-18 and IL-10 levels in prostate tissues.
  • Cytokine profiles were distinct between prostate cancer and BPH cases.
  • IL-18 and IL-10 show potential for noninvasive diagnosis and risk assessment.

Abstract

NF-κB and its downstream cytokines, IL-18 and IL-10, may serve as inflammation-driven, noninvasive biomarkers for prostate cancer diagnosis, staging, and risk stratification, particularly in populations exposed to environmental factors.

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Cite This Study

Dwivedi et al. (2026) studied this question.

synapsesocial.com/papers/69746090bb9d90c67120a5cdhttps://doi.org/10.31557/apjcp.2026.27.1.381
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NF-κB Signaling in Prostate Cancer Progression: Inflammatory Mediators, Survival Pathways, and Regulatory Axes2026
  2. 2The Infiltration of IL‐18‐Related Immune Cells and Their Bidirectional Regulatory Roles in the Pathogenesis of Prostate Cancer2025
  3. 3Expression and immune infiltration studies of IL‐33‐ST2‐NF‐κB signaling pathway in prostate cancer2024 · 2 citations
  4. 4NF-κB in biology and targeted therapy: new insights and translational implications2024 · 1,943 citations
  5. 5Immunological Interactions and Inflammatory Changes in the Pathways of Benign Prostatic Hyperplasia and Prostate Cancer2025