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January 24, 2026ISME CommunicationsOpen Access

Pseudovibriamide B from marine sponge-associated bacteria acts as a selective antibiotic antidote

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Authors

VLVitor B. LourenzonYDYitao DaiMTMandisa Timba

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Overview

This research finds that pseudovibriamide B selectively protects certain bacteria from antibiotics, suggesting a natural antidote strategy.

Key Points

  • The study aims to determine whether pseudovibriamide B can act as a selective antidote to the broad-spectrum antibiotic blasticidin S.
  • Investigated the antidote potential of pseudovibriamide B produced by Pseudovibrio brasiliensis Ab134.
  • Developed an overexpression strategy for core biosynthetic genes to enhance pseudovibriamide B production.
  • Established a Minimum Antidote Concentration (MAC) assay for evaluating antidote activity.
  • Pseudovibriamide B production increased more than three-fold through the overexpression strategy.
  • The MAC assay identified that pseudovibriamide B selectively protects Bacillus cereus and a marine sponge-associated Bacillus sp.
  • No protection was observed in pathogens or other sponge-associated isolates, indicating narrow-spectrum activity.

Cite This Study

Lourenzon et al. (2026) studied this question.

synapsesocial.com/papers/697460cebb9d90c67120aa2ahttps://doi.org/10.1093/ismeco/ycag014
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