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January 24, 2026RSC Advances0 citationsOpen Access

Stereoselective 15α-hydroxylation of androsta-1,4-diene-3,17-dione by Gibberella sp. for efficient production of 15α-OH-ADD and 15α-OH-AD

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RHRan HeMSMing SongRFRuicheng Fu

Key Points

  • The research aims to optimize the biocatalytic hydroxylation of steroids using Gibberella sp. to produce specific intermediates.
  • Utilized Gibberella sp. for steroid biotransformation
  • Identified products through biocatalytic processes
  • Optimized conditions for maximum hydroxylation efficiency
  • Successfully produced 15α-OH-ADD and 15α-OH-AD
  • Demonstrated the potential for industrial-scale steroid synthesis
  • Achieved efficient enzymatic conversion rates

Abstract

Biocatalytic hydroxylation of steroids by Gibberella sp. in steroid intermediate synthesis. Products identification and biotransformation optimization. Efficient 15α-OH-ADD production and industrial potential by Gibberella sp.

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Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/6974610cbb9d90c67120af6ehttps://doi.org/10.1039/d5ra08374e
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