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January 24, 2026Rejuvenation Research

Evaluating the Therapeutic Potential of Hyriopsis cumingii Polysaccharide in Osteoarthritis: Insights from a Mouse Model

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Authors

HSHai-liang SunNWNattaya WichienwantanaWWWei-kiat Wong

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Overview

Evaluates HCP's effects on osteoarthritis in mice, suggesting a promising therapeutic option.

Key Points

  • The research aims to evaluate the protective effects of Hyriopsis cumingii polysaccharide on osteoarthritis in mouse models.
  • Injected monosodium iodoacetate into mice to induce osteoarthritis
  • Conducted behavioral analysis for pain assessment
  • Measured serum antioxidant levels and pro-inflammatory cytokines
  • Examined cartilage morphology through staining and microcomputed tomography
  • Analyzed gut microbiota using high-throughput fecal 16S rRNA sequencing
  • HCP improved gait and increased serum antioxidant levels (SOD, GSH-Px, CAT)
  • Reduced levels of inflammatory markers (TNF-α, IL-6) in cartilage
  • Improved cartilage surface morphology and inhibited bone destruction
  • Elevated expression of type II collagen and decreased expression of matrix metalloproteinases and inflammatory cytokines
  • Regulated gut microbiota diversity, increasing Firmicutes and decreasing Bacteroidetes and Proteobacteria

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69746149bb9d90c67120b244https://doi.org/10.1177/15491684251414069
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