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January 24, 2026Asian Pacific Journal of Cancer Prevention0 citationsOpen Access

The Genetic Polymorphisms of DNA Repair Gene RAD51 and Their Role as a Predictive Biomarker for Breast Cancer Risk and Response to Radiotherapy in Iraqi Women

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HAHaael Subhi AbbasAMAli Abdul Hussein MahdiNTNihad Khalawe Tektook

Key Points

  • The aim is to explore the role of RAD51 genetic polymorphisms in predicting breast cancer risk and response to radiotherapy.
  • Analyzed the association of RAD51 polymorphisms with breast cancer risk in Iraqi women.
  • Investigated the response to radiotherapy based on RAD51 genotypes.
  • Identified the protective effects of specific RAD51 genotypes against breast cancer.
  • The RAD51 (G>T) polymorphism was significantly associated with breast cancer risk.
  • Patients with the GT genotype and T allele showed improved responses to radiotherapy.
  • The RAD51 (G>C) GG genotype may offer protective benefits against breast cancer.

Abstract

The Iraqi BC risk was associated with the RAD51 (G>T) polymorphism. GT genotype / T allele patients responded well to RT, indicating that RAD51 might predict cancer risk and RT effectiveness. Iraqi women may benefit from the RAD51 (G>C) GG genotype in protection against BC.

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Cite This Study

Abbas et al. (2026) studied this question.

synapsesocial.com/papers/697461a8bb9d90c67120b766https://doi.org/10.31557/apjcp.2026.27.1.345
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