Enantioselective Michael additions promoted by a bifunctional charge-activated thiourea catalyst

Key Points

• The aim is to synthesize a new bifunctional thiourea catalyst and evaluate its enantioselective activity.
• Development of a new bifunctional thiourea catalyst with a methylated pyridinium ion and chiral amine.
• Comparison of catalytic activity against Takemoto's catalyst in Michael addition reactions.
• The new organocatalyst shows increased activity compared to analogous thiourea catalysts.
• Significant improvement in enantioselectivity observed during Michael addition reactions.