Dose-dependent neurotoxic chemotherapy and corneal nerve morphological changes.

Key Points

• The study aims to investigate the relationship between chemotherapy dose and morphological changes in corneal nerves as a potential marker for chemotherapy-induced peripheral neuropathy (CIPN).
• Evaluated corneal nerve morphology using imaging techniques.
• Analyzed nerve fibre length in relation to chemotherapy dosage.
• Examined different areas of the sub-basal corneal nerve plexus.
• Average nerve fibre length showed significant loss correlating with increased chemotherapy dosage.
• Wider imaging of the sub-basal corneal nerve plexus may reveal earlier neuropathic changes.
• The inferior whorl region provided additional insights into nerve alterations.

Abstract