Treatment of desmoplastic small round cell tumor in the seminal vesicle with chemotherapy, surgery, and radiation led to a partial response in the patient.
1 male patient, 30 years old, with Desmoplastic small round cell tumor (DSRCT) of the seminal vesicle.
4 cycles of Vincristine, Adriamycin, and Cyclophosphamide (VAC) alternating with Ifosfamide and Etoposide (IE) chemotherapy, followed by debulking surgery and post-op radiation therapy, then 6 further cycles of chemotherapy.
Treatment response
Multimodality treatment including chemotherapy, surgery, and radiation therapy can yield a good short-term response in rare cases of DSRCT of the seminal vesicle.
Desmoplastic small round cell tumor (DSRCT) is an aggressive, uncommon disease and difficult to diagnose and identified by translocation t(11;22) (p13;q12) leading to fusion transcript EWSR1–WT1 . A case of DSRCT of the seminal vesicle diagnosed by histopathology, immunohistochemistry, and genetic study, and treated with chemotherapy, surgery, and radiation therapy on the lines of Ewing Sarcoma protocol is presented. Four cycles of chemotherapy was given, and he had a partial response, so underwent debulking surgery followed by radiation therapy.
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Vanshika Rastogi
Sushila Jaiswal
N. Rastogi
Asian Journal of Oncology
Sanjay Gandhi Post Graduate Institute of Medical Sciences
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Rastogi et al. (Fri,) reported a other. Treatment of desmoplastic small round cell tumor in the seminal vesicle with chemotherapy, surgery, and radiation led to a partial response in the patient.
www.synapsesocial.com/papers/6975b36bfeba4585c2d6ee4e — DOI: https://doi.org/10.25259/asjo_58_2025