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January 25, 20260 citations

Natural Product-Based Virtual Screening Identifies Potential Inhibitors of Feline Coronavirus 3CLpro.

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ZJZunyun JiangHCHongyi ChenWXWang Xiong

Key Points

  • The study aims to identify potential inhibitors of feline coronavirus 3CLpro using natural product-based virtual screening.
  • Conducted virtual screening of natural compounds.
  • Focused on identifying strong antiviral candidates.
  • Analyzed core molecular frameworks for inhibitor potential.
  • Identified several compounds with strong antiviral potential.
  • Revealed molecular frameworks for designing new inhibitors.
  • Laid the groundwork for further structure-guided drug discovery.

Abstract

The findings indicated the compounds' strong potential for further development as antiviral leads. The results also revealed several core molecular frameworks that may serve as an initial reference for designing FCoV 3CLpro inhibitors, laying the groundwork for structure-guided drug discovery efforts.

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Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6975b4fd5a65d392b01e5d03https://doi.org/10.2174/0115680266426906251125112131
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