Knee osteoarthritis is a prevalent degenerative joint disorder characterised by the gradual deterioration of the protective cartilage in the knee with limiting treatment options. A 55-year-old male with symptomatic knee osteoarthritis underwent a novel two-phase regenerative treatment combining micro-fragmented adipose tissue injection with metabolic solution infiltration. The patient presented with medial and anterior knee pain (visual analogue scale - VAS 4.5, knee injury and osteoarthritis outcome score - KOOS 64 %). Treatment involved intra-articular injection of 20-40-micron microfiltered adipose tissue followed by a solution containing non-crosslinked hyaluronic acid, branched amino acids and sodium bicarbonate to activate membrane glycoproteins and drive adipose-derived stem cells (ADSCa) to exosome budding. At six months, dramatic improvement was observed with VAS decreasing to 0.5 and KOOS increasing to 95 %. No adverse reactions occurred. This minimally invasive technique represents a promising approach for early-stage knee osteoarthritis treatment.
Svolacchia et al. (Wed,) studied this question.
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