What question did this study set out to answer?

The main aim is to develop a direct allylic C-H glycosylation reaction using cobalt catalysis.

February 2, 2026

Cobaloxime-Catalyzed Radical C-Allyl Glycoside Assembly

Key Points

The main aim is to develop a direct allylic C-H glycosylation reaction using cobalt catalysis.
Utilized photoredox-halogen atom transfer in conjunction with cobalt catalysis.
Synthesized C-alkyl glycosides via Giese addition.
Captured alkyl radical intermediates with CoII to facilitate the reaction.
Successfully produced valuable allyl glycosylation products.
Demonstrated compatibility with late-stage functionalization of pharmaceutical molecules.
Indicated potential for scalable production in synthetic applications.

Abstract

A direct allylic C-H glycosylation reaction is described, which involves the synergistic merger of photoredox-halogen atom transfer (XAT)/cobalt catalysis. This reaction enhances the application of Giese addition in the synthesis of C-alkyl glycosides by CoII capturing the alkyl radical intermediate/β-hydrogen abstraction to deliver highly valuable allyl glycosylation products. Moreover, the compatibility with the late-stage functionalization of pharmaceutical molecules and the potential for scalable production underscore the practical utility of this protocol in synthetic applications.

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