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February 2, 2026Chemical Science0 citationsOpen Access

Continuous Flow Unlocks Modular Ketones Assembly Enabled by Dynamic Orbital Selection

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JWJiayin WangSZShuangshuang ZhouXHXinyao Hu

Key Points

  • The study aims to enhance ketone synthesis by addressing limitations in existing cross-coupling methods.
  • Utilized continuous flow techniques to improve reaction conditions.
  • Explored diverse structural motifs for ketone assembly.
  • Assessed redox conditions for optimal performance.
  • Evaluated scalability of synthesis methods.
  • Expanded substrate scope for ketone synthesis significantly.
  • Achieved improved efficiency under neutral redox conditions.
  • Demonstrated scalability suited for larger applications.

Abstract

Cross-coupling based on diverse structural motifs offers a powerful strategy for ketone synthesis. However, existing methodologies are often hampered by a narrow substrate scope, non-neutral redox conditions, and poor scalability,...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6980fc37c1c9540dea80df70https://doi.org/10.1039/d5sc09414c
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