Analysis evaluates genetic risk and dietary habits in predicting activity and weight changes in adults, suggesting complex interactions.
Key Points
The study aims to evaluate the predictive value of polygenic risk scores for physical activity and weight outcomes, particularly in interaction with diet.
Analyzed baseline data from 202 participants in the iMPROVE study
Calculated polygenic risk scores for 197 participants
Operationalized physical activity using metabolic equivalent of task minutes per week
Examined interactions between genetic data and dietary patterns with correlation analyses and regression models
Polygenic risk score PGS002254 showed a significant interaction with diet for weight loss post-intervention (p = 0.04)
Sedentary behavior score PGS001923 had a significant interaction with a dietary pattern for MET-mins/week (p = 0.001)
Genetic predisposition influences activity and weight outcomes but has modest explanatory power