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Synapse
February 2, 2026European journal of medical research0 citationsOpen Access

Identification of the biomarkers associated with lipid metabolism and endoplasmic reticulum stress in pediatric sepsis through bioinformatics analysis and quantitative reverse transcriptase PCR (qRT-PCR) assay

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BSBaoju ShanJCJiaoyang CaoTYTing Yang

Key Points

  • The aim is to identify biomarkers associated with lipid metabolism and endoplasmic reticulum stress in pediatric sepsis.
  • Utilized bioinformatics analysis to identify potential biomarkers.
  • Conducted quantitative reverse transcriptase PCR (qRT-PCR) to validate findings.
  • Identified four key biomarkers: ACER3, DGAT2, GBA, and TSPO.
  • These biomarkers are linked to lipid metabolism and endoplasmic reticulum stress in pediatric sepsis.
  • Findings provide insights into potential treatment strategies for pediatric sepsis.

Abstract

A total of 4 biomarkers (ACER3, DGAT2, GBA, and TSPO) related to lipid metabolism and endoplasmic reticulum stress in pediatric sepsis were identified. These biomarkers offered fresh insights into the mechanisms and therapeutic approaches of pediatric sepsis.

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Cite This Study

Shan et al. (2026) studied this question.

synapsesocial.com/papers/6980fd18c1c9540dea80ed32https://doi.org/10.1186/s40001-026-03931-x
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