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February 2, 2026Stroke

Abstract WP350: Integrative Proteomic Profiling Reveals Sex-Specific Pathways in Socially Isolated Stroke Patients

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Authors

MHMAYA HOFFMANLCLucy CoutureBABanerjee Ak

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Overview

Integrative profiling demonstrates sex-specific differences in stroke recovery in socially isolated patients, indicating implications for tailored therapies.

Key Points

  • The aim is to understand how sex differences and social isolation impact post-stroke recovery through proteomic profiling.
  • Conducted plasma proteomic profiling using Single-Run LC-MS/MS in 154 ischemic stroke patients.
  • Measured social isolation using the Lubben Social Network Scale and loneliness with the UCLA Loneliness Scale.
  • Analyzed sex-specific alterations in immune, vascular, and metabolic pathways related to stroke recovery.
  • Males showed significant enrichment in coagulation and vascular inflammation pathways associated with loneliness scores.
  • Females had distinct immune and vascular regulatory pathways linked to loneliness, highlighting sex-specific responses.
  • Key proteins like C3, C4A, and C4B were enriched in females, emphasizing their role in neuroimmune responses and social behavior.

Cite This Study

HOFFMAN et al. (2026) studied this question.

synapsesocial.com/papers/6980fd60c1c9540dea80f0e1https://doi.org/10.1161/str.57.suppl_1.wp350
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract WP291: Genome-Wide Transcriptomic Analysis of Sex- and Social Isolation–Dependent Gene Expression Following Ischemic Stroke2026
  2. 2Abstract DP366: Sex-Specific Metabolomic Signatures of Social Isolation After Ischemic Stroke2026
  3. 3Sex differences in proteomic response to ischemic stroke2026
  4. 4Abstract TH982: Proteomic Profiles and Pathways of Ischemic Stroke Risk in Women from the Nurses’ Health Study2026
  5. 5Abstract WE564: Identifying Sex Differences in Proteins Associated with Incident Ischemic Stroke in the UK Biobank2026