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February 2, 2026BMC CancerOpen Access

Integrated single-cell and bulk RNA sequencing unravels neutrophil heterogeneity and validates SPP1 as a prognostic biomarker in cervical cancer

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Authors

SLSiting LinJZJunlin ZhongSYShengjin Yuan

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Overview

Integrated analysis demonstrates SPP1's potential to improve risk stratification in cervical cancer patients, suggesting new therapeutic approaches.

Key Points

  • The study aims to characterize the tumor microenvironment in cervical cancer and validate SPP1 as a prognostic biomarker.
  • Performed single-cell RNA sequencing to analyze the tumor microenvironment.
  • Used bulk RNA sequencing for integrated analysis.
  • Identified SPP1 as an oncogenic driver and prognostic signature.
  • SPP1 was validated as a significant prognostic biomarker.
  • The integrated model showed utility for risk stratification in cervical cancer patients.
  • New insights into neutrophil heterogeneity within the tumor microenvironment were established.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6980fd60c1c9540dea80f12ahttps://doi.org/10.1186/s12885-026-15636-9
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