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February 2, 2026Arteriosclerosis Thrombosis and Vascular Biology

Bmal1 Regulates Vascular Calcification via Noncanonical Circadian Pathway

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Authors

MHMing HeYSYong SunCTChengyun Tang

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Overview

This research uncovers how Bmal1 contributes to vascular calcification in diabetes, indicating new therapeutic possibilities.

Key Points

  • The study aims to explore the role of Bmal1 protein in vascular calcification associated with diabetes.
  • Examination of Bmal1 expression in diabetic mouse aortas and human arterial tissues.
  • Generation of SMC-specific Bmal1 knockout mice and assessment of diabetes-induced conditions.
  • Utilization of RNA sequencing and chromatin immunoprecipitation for molecular mechanism analysis.
  • Bmal1 expression was significantly upregulated in diabetic arteries and vascular smooth muscle cells under high glucose.
  • Knockout of Bmal1 in SMCs reduced vascular calcification and stiffness, and lowered osteogenic gene expression.
  • RNA sequencing revealed Bmal1-dependent genes related to osteogenic differentiation and extracellular matrix organization.

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/6980fd9dc1c9540dea80f698https://doi.org/10.1161/atvbaha.125.324061
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