Unbiased screening identifies CSF microRNA-144-3p as a predictor of long-term outcomes in subarachnoid hemorrhage, suggesting potential clinical utility.
Key Points
To identify microRNA biomarkers in cerebrospinal fluid that predict long-term outcomes in subarachnoid hemorrhage (SAH).
Prospective cohort study involving 65 SAH patients and 15 controls.
Stored cerebrospinal fluid samples during acute SAH phase.
Assessed functional outcomes using modified Rankin Score at 3 and 6 months post-SAH.
Recorded angiographic vasospasm based on cerebral vessel caliber.
Conducted unbiased screening of 798 microRNAs using the Nanostring nCounter system.
Mean age of SAH cohort was 55.8 years, with 67.7% being female.
49.2% of patients developed vasospasm.
CSF microRNA-144-3p was one of the most differentially expressed, significantly higher in SAH than controls.
Higher levels of miR-144-3p were associated with unfavorable outcomes at 3 and 6 months post-SAH.